FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice.

• Main Authors: Beibei Zhang (Author), Jing Li (Author), Xianlong Zong (Author), Jianling Wang (Author), Lianlian Xin (Author), Haiyao Song (Author), Wenxue Zhang (Author), Stephane Koda (Author), Hui Hua (Author), Bo Zhang (Author), Qian Yu (Author), Kui-Yang Zheng (Author), Chao Yan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Schistosomiasis, with 250 million people affected, is characterized by its serious hepatic inflammatory response and fibrosis formation, which could lead to dangerous complications, such as portal hypertension, splenomegaly and even ascites. But until now, the pathogen...