Engineering Cellular Resistance to HIV-1 Infection In Vivo Using a Dual Therapeutic Lentiviral Vector

• Main Authors: Bryan P Burke (Author), Bernard R Levin (Author), Jane Zhang (Author), Anna Sahakyan (Author), Joshua Boyer (Author), Maria V Carroll (Author), Joanna Camba Colón (Author), Naomi Keech (Author), Valerie Rezek (Author), Gregory Bristol (Author), Erica Eggers (Author), Ruth Cortado (Author), Maureen P Boyd (Author), Helen Impey (Author), Saki Shimizu (Author), Emily L Lowe (Author), Gene-Errol E Ringpis (Author), Sohn G Kim (Author), Dimitrios N Vatakis (Author), Louis R Breton (Author), Jeffrey S Bartlett (Author), Irvin S Y Chen (Author), Scott G Kitchen (Author), Dong Sung An (Author), Geoff P Symonds (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We described earlier a dual-combination anti-HIV type 1 (HIV-1) lentiviral vector (LVsh5/C46) that downregulates CCR5 expression of transduced cells via RNAi and inhibits HIV-1 fusion via cell surface expression of cell membrane-anchored C46 antiviral peptide. This combinatorial approach has two poi...