Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system

• Main Authors: Xusheng Wang (Author), Haiyan Chen (Author), Xiaowei Zeng (Author), Wenpeng Guo (Author), Yu Jin (Author), Shan Wang (Author), Ruiyun Tian (Author), Yanjiang Han (Author), Ling Guo (Author), Jimin Han (Author), Yaojiong Wu (Author), Lin Mei (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel (DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases. KEY WORDS: Mesenchymal stem cells, Nanoparticle, Drug delivery, KrasG12D, Lung cancer

Item Description

2211-3835
10.1016/j.apsb.2018.08.006