New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases

CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph nodes, initiating the antigen presentation and T-cell response. Abnormal expression of CCR7 in dendritic cells will cause a...

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Main Authors: Wenxiang Hong (Author), Bo Yang (Author), Qiaojun He (Author), Jiajia Wang (Author), Qinjie Weng (Author)
Format: Book
Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
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100 1 0 |a Wenxiang Hong  |e author 
700 1 0 |a Bo Yang  |e author 
700 1 0 |a Qiaojun He  |e author 
700 1 0 |a Qiaojun He  |e author 
700 1 0 |a Qiaojun He  |e author 
700 1 0 |a Jiajia Wang  |e author 
700 1 0 |a Qinjie Weng  |e author 
700 1 0 |a Qinjie Weng  |e author 
245 0 0 |a New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases 
260 |b Frontiers Media S.A.,   |c 2022-02-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2022.841687 
520 |a CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph nodes, initiating the antigen presentation and T-cell response. Abnormal expression of CCR7 in dendritic cells will cause a series of inflammatory diseases due to the chaotic dendritic cell trafficking. In this review, we take an in-depth look at the structural-functional domains of CCR7 and CCR7-bearing dendritic cell trajectory to lymph nodes. Then, we summarize the regulatory network of CCR7, including transcriptional regulation, translational and posttranslational regulation, internalization, desensitization, and recycling. Furthermore, the potential strategies of targeting the CCR7 network to regulate dendritic cell migration and to deal with inflammatory diseases are integrated, which not only emphasizes the possibility of CCR7 to be a potential target of immunotherapy but also has an implication on the homing of dendritic cells to benefit inflammatory diseases. 
546 |a EN 
690 |a CCR7 
690 |a dendritic cells 
690 |a migration 
690 |a regulatory network 
690 |a immunotherapy 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
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786 0 |n Frontiers in Pharmacology, Vol 13 (2022) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fphar.2022.841687/full 
787 0 |n https://doaj.org/toc/1663-9812 
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