Single Intramuscular-dose Toxicity of Samgihwalryeok-Pharmacopuncture in Sprague-Dawley Rats

• Main Authors: Sung-Chul Kim (Author), Seong-Hun Ahn (Author)
• Format: Book
• Published: Korean Pharmacopuncture Institute, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3831/KPI.2014.17.016; 2093-6966; 2234-6856
• Keywords: acupuncture; pharmacopuncture; Samgihwalryeok pharmacopuncture; single toxicity test; Medicine; R; Miscellaneous systems and treatments; RZ409.7-999; Therapeutics. Pharmacology; RM1-950
• Source: Journal of Pharmacopuncture, Vol 17, Iss 2, Pp 46-56 (2014)

Objectives:This study was performed to examine the single-dose toxicity of Samgihwalryeok pharmacopuncture. Methods:Forty six-week-old Sprague-Dawley (SD) rats were divided into four groups of 10 rats each; each group was then sub-divided into two smaller groups, one of five males and the other of five females. Group 1 (G1, control) received 1.0 mL of normal saline solution, while group 2 (G2, low-dose group), group 3 (G3, mid-does group, and group 4 (G4, high-dose group) received 0.1, 0.5, and 1.0 mL of Samgihwalryeok pharmacopuncture, respectively. Results:No mortalities or clinical signs were observed in the four groups. Also, no significant changes in body weights were observed among the group, and no significant differences in hematology/biochemistry, necropsy, or histopathology results were noted. Conclusion:The above findings suggest that treatment with Samgihwalryeok pharmacopuncture is relatively safe. Further studies on this subject are needed.