Potential Roles of Hypoxia-Inducible Factor-1 in Alzheimer's Disease: Beneficial or Detrimental?

• Main Authors: Tsu-Kung Lin (Author), Chi-Ren Huang (Author), Kai-Jung Lin (Author), Yi-Heng Hsieh (Author), Shang-Der Chen (Author), Yi-Chun Lin (Author), A-Ching Chao (Author), Ding-I Yang (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The major pathological characteristics of Alzheimer's disease (AD) include senile plaques and neurofibrillary tangles (NFTs), which are mainly composed of aggregated amyloid-beta (Aβ) peptide and hyperphosphorylated tau protein, respectively. The excessive production of reactive oxygen species...