Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS
Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRPRPRPL-CONH2 and Bac5-v291: RWRRPIRRRPIRPPFWR-CONH2) were comb...
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Main Authors: | Kai Hilpert (Author), Jurnorain Gani (Author), Christoph Rumancev (Author), Nathan Simpson (Author), Paula Matilde Lopez-Perez (Author), Vasil M. Garamus (Author), Andreas Robert von Gundlach (Author), Petar Markov (Author), Marco Scocchi (Author), Ralf Mikut (Author), Axel Rosenhahn (Author) |
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Format: | Book |
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Frontiers Media S.A.,
2021-12-01T00:00:00Z.
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