Antibacterial Activity of LCB10-0200 against <i>Klebsiella pneumoniae</i>
<i>Klebsiella pneumoniae</i> is one of the important clinical organisms that causes various infectious diseases, including urinary tract infections, necrotizing pneumonia, and surgical wound infections. The increase in the incidence of multidrug-resistance <i>K. pneumoniae</i>...
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| Main Authors: | , , , , , |
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| Format: | Book |
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MDPI AG,
2021-09-01T00:00:00Z.
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| Summary: | <i>Klebsiella pneumoniae</i> is one of the important clinical organisms that causes various infectious diseases, including urinary tract infections, necrotizing pneumonia, and surgical wound infections. The increase in the incidence of multidrug-resistance <i>K. pneumoniae</i> is a major problem in public healthcare. Therefore, a novel antibacterial agent is needed to treat this pathogen. Here, we studied the in vitro and in vivo activities of a novel antibiotic LCB10-0200, a siderophore-conjugated cephalosporin, against clinical isolates of <i>K. pneumoniae</i>. In vitro susceptibility study found that LCB10-0200 showed potent antibacterial activity against <i>K. pneumoniae</i>, including the beta-lactamase producing strains. The in vivo efficacy of LCB10-0200 was examined in three different mouse infection models, including systemic, thigh, and urinary tract infections. LCB10-0200 showed more potent in vivo activity than ceftazidime in the three in vivo models against the drug-susceptible and drug-resistant <i>K. pneumoniae</i> strains. Taken together, these results show that LCB10-0200 is a potential antibacterial agent to treat infection caused by <i>K. pneumoniae</i>. |
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| Item Description: | 10.3390/antibiotics10101185 2079-6382 |