Rapid development of HPV-mediated oropharyngeal squamous cell carcinoma in the setting of immune suppression following autologous stem cell transplantation for Hodgkin lymphoma
The patient is a 61-year-old male with a diagnosis of relapse classical Hodgkin lymphoma, treated with ABVD, ICE, and achieved remission. He underwent autologous stem cell transplantation and 3 months later found to have a PET-positive neck node concerning for relapsed disease of Hodgkin lymphoma. B...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2017-09-01T00:00:00Z.
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| Summary: | The patient is a 61-year-old male with a diagnosis of relapse classical Hodgkin lymphoma, treated with ABVD, ICE, and achieved remission. He underwent autologous stem cell transplantation and 3 months later found to have a PET-positive neck node concerning for relapsed disease of Hodgkin lymphoma. Biopsy proved the lesion was HPV-associated squamous cell carcinoma and not relapse Hodgkin disease. Iatrogenic immunosuppression such as bone marrow transplantation can cause substantial increase risk for viral-associated tumors and therefore tissue biopsies are necessary to make that distinction to avoid inappropriate treatment. Keywords: Hodgkin lymphoma, HPV, Squamous cell carcinoma, Transplantation |
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| Item Description: | 2214-3300 10.1016/j.ehpc.2016.10.001 |