Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population

• Main Authors: Mina Hassani (Author), Kioomars Saliminejad (Author), Masood Heidarizadeh (Author), Koorosh Kamali (Author), Toktam Memariani (Author), Hamid Reza Khorram Khorshid (Author)
• Format: Book
• Published: Shahid Sadoughi University of Medical Science, Yazd, Iran, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1680-6433; 2008-2177
• Keywords: Gynecology and obstetrics; RG1-991; Reproduction; QH471-489
• Source: Iranian Journal of Reproductive Medicine, Vol 14, Iss 4, Pp 241-246 (2016)

Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent. Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population. Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods. Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%). Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women. Key