Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the...
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| Egile Nagusiak: | , , |
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| Formatua: | Liburua |
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Elsevier,
2005-01-01T00:00:00Z.
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| Gaia: | The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the α- and β-chains of fibrinogen, whereas plasma NO2− level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that L-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase. Keywords:: fibrinogen, NG-nitro-L-arginine-methyl ester, mRNA |
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| Alearen deskribapena: | 1347-8613 10.1254/jphs.scj05001x |