Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

• Автори: Young D. Kwon (Автор), Amarendra Pegu (Автор), Eun Sung Yang (Автор), Baoshan Zhang (Автор), Michael F. Bender (Автор), Mangaiarkarasi Asokan (Автор), Qingbo Liu (Автор), Krisha McKee (Автор), Bob C. Lin (Автор), Tracy Liu (Автор), Mark K. Louder (Автор), Reda Rawi (Автор), Mateo Reveiz (Автор), Andrew J. Schaub (Автор), Chen-Hsiang Shen (Автор), Nicole A. Doria-Rose (Автор), Paolo Lusso (Автор), John R. Mascola (Автор), Peter D. Kwong (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

ABSTRACTThe amino-acid composition of the immunoglobulin variable region has been observed to impact antibody pharmacokinetics (PK). Here, we sought to improve the PK of the broad HIV−1-neutralizing VRC01-class antibodies, VRC07-523LS and N6LS, by reducing the net positive charge in their variable d...