Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

• Main Authors: Young D. Kwon (Author), Amarendra Pegu (Author), Eun Sung Yang (Author), Baoshan Zhang (Author), Michael F. Bender (Author), Mangaiarkarasi Asokan (Author), Qingbo Liu (Author), Krisha McKee (Author), Bob C. Lin (Author), Tracy Liu (Author), Mark K. Louder (Author), Reda Rawi (Author), Mateo Reveiz (Author), Andrew J. Schaub (Author), Chen-Hsiang Shen (Author), Nicole A. Doria-Rose (Author), Paolo Lusso (Author), John R. Mascola (Author), Peter D. Kwong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe amino-acid composition of the immunoglobulin variable region has been observed to impact antibody pharmacokinetics (PK). Here, we sought to improve the PK of the broad HIV−1-neutralizing VRC01-class antibodies, VRC07-523LS and N6LS, by reducing the net positive charge in their variable d...