Excellent response to adalimumab in a patient with Papillon-Lefèvre syndrome: A case report

Abstract Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disease that presents clinically with palmoplantar keratoderma and periodontitis and results in early‐onset dental loss. PLS management is difficult. We report a 30‐year‐old female with PLS who had unfavourable response to topica...

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Main Authors: Eman Almukhadeb (Author), Wael Alanazi (Author), Rahaf Alshareef (Author), Feras Altukhaim (Author), Amal Albalbeesi (Author)
Format: Book
Published: Wiley, 2023-09-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Eman Almukhadeb  |e author 
700 1 0 |a Wael Alanazi  |e author 
700 1 0 |a Rahaf Alshareef  |e author 
700 1 0 |a Feras Altukhaim  |e author 
700 1 0 |a Amal Albalbeesi  |e author 
245 0 0 |a Excellent response to adalimumab in a patient with Papillon-Lefèvre syndrome: A case report 
260 |b Wiley,   |c 2023-09-01T00:00:00Z. 
500 |a 2768-6566 
500 |a 10.1002/jvc2.184 
520 |a Abstract Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disease that presents clinically with palmoplantar keratoderma and periodontitis and results in early‐onset dental loss. PLS management is difficult. We report a 30‐year‐old female with PLS who had unfavourable response to topical keratolytic creams, oral isotretinoin and narrow‐band ultraviolet‐B (NB‐UVB) phototherapy but showed significant clinical improvement to adalimumab. 
546 |a EN 
690 |a adalimumab 
690 |a palmoplantar keratoderma 
690 |a Papillon-Lefevre syndrome 
690 |a Dermatology 
690 |a RL1-803 
690 |a Diseases of the genitourinary system. Urology 
690 |a RC870-923 
655 7 |a article  |2 local 
786 0 |n JEADV Clinical Practice, Vol 2, Iss 3, Pp 621-624 (2023) 
787 0 |n https://doi.org/10.1002/jvc2.184 
787 0 |n https://doaj.org/toc/2768-6566 
856 4 1 |u https://doaj.org/article/40a7e8205f494763b4b5ea6f19e000c0  |z Connect to this object online.