Flos puerariae ameliorates the intestinal inflammation of Drosophila via modulating the Nrf2/Keap1, JAK-STAT and Wnt signaling
Gut homeostasis is important for human health, and its disruption can lead to inflammatory bowel disease (IBD). Flos Puerariae is a herb with a wide variety of pharmacological activities including antioxidant, antidiabetic, antialcoholismic and anti-inflammatory properties. However, the role of Flos...
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Frontiers Media S.A.,
2022-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_40d970ee05da45ae9e83cfe50bd2e15b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shipei Yang |e author |
| 700 | 1 | 0 | |a Shipei Yang |e author |
| 700 | 1 | 0 | |a Xu Li |e author |
| 700 | 1 | 0 | |a Minghui Xiu |e author |
| 700 | 1 | 0 | |a Minghui Xiu |e author |
| 700 | 1 | 0 | |a Minghui Xiu |e author |
| 700 | 1 | 0 | |a Yuting Dai |e author |
| 700 | 1 | 0 | |a Shengfang Wan |e author |
| 700 | 1 | 0 | |a Yan Shi |e author |
| 700 | 1 | 0 | |a Yan Shi |e author |
| 700 | 1 | 0 | |a Yongqi Liu |e author |
| 700 | 1 | 0 | |a Yongqi Liu |e author |
| 700 | 1 | 0 | |a Jianzheng He |e author |
| 700 | 1 | 0 | |a Jianzheng He |e author |
| 700 | 1 | 0 | |a Jianzheng He |e author |
| 245 | 0 | 0 | |a Flos puerariae ameliorates the intestinal inflammation of Drosophila via modulating the Nrf2/Keap1, JAK-STAT and Wnt signaling |
| 260 | |b Frontiers Media S.A., |c 2022-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.893758 | ||
| 520 | |a Gut homeostasis is important for human health, and its disruption can lead to inflammatory bowel disease (IBD). Flos Puerariae is a herb with a wide variety of pharmacological activities including antioxidant, antidiabetic, antialcoholismic and anti-inflammatory properties. However, the role of Flos Puerariae on treating IBD remains obscure. Here, we employed Drosophila melanogaster as a model organism to investigate the protective effect of Flos Puerariae extract (FPE) against sodium dodecyl sulfate (SDS)-induced intestinal injury. Our data showed that FPE had no toxic effect in flies, and significantly extended lifespan in SDS-inflamed flies, reduced stem cell proliferation in the midgut, and maintained intestinal morphological integrity. Furthermore, FPE remarkably recused the altered expression level of genes and proteins in Nrf2/Keap1 signaling, JAK-STAT signaling and Wnt signaling pathways in gut of inflammation flies. Thus, FPE has a protective effect against intestinal injury possibly via increasing the Nrf2/keap1 pathway and suppressing the JAK-STAT and Wnt signaling pathways, which would have tremendous potential for treating IBD. | ||
| 546 | |a EN | ||
| 690 | |a Flos Puerariae | ||
| 690 | |a intestinal inflammation | ||
| 690 | |a intestinal homeostasis | ||
| 690 | |a Drosophila melanogaster | ||
| 690 | |a intestinal stem cells | ||
| 690 | |a ROS | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.893758/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/40d970ee05da45ae9e83cfe50bd2e15b |z Connect to this object online. |