Molecular Determinants for OMF Selectivity in Tripartite RND Multidrug Efflux Systems

• Main Authors: Esther Boyer (Author), Jean Dessolin (Author), Margaux Lustig (Author), Marion Decossas (Author), Gilles Phan (Author), Quentin Cece (Author), Grégory Durand (Author), Véronique Dubois (Author), Joris Sansen (Author), Jean-Christophe Taveau (Author), Isabelle Broutin (Author), Laetitia Daury (Author), Olivier Lambert (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tripartite multidrug RND efflux systems made of an inner membrane transporter, an outer membrane factor (OMF) and a periplasmic adaptor protein (PAP) form a canal to expel drugs across Gram-negative cell wall. Structures of MexA-MexB-OprM and AcrA-AcrB-TolC, from <i>Pseudomonas aeruginosa</...