GLP-1 RA for cardiometabolic risk reduction in obesity - How do we best describe benefit and value?
How do we assess the overall benefit and value of GLP1-RAs? Current clinical trials often focus narrowly on individual atherosclerotic cardiovascular endpoints like MACE, potentially missing broader GLP-1 RA benefits across multiple comorbidities. Herein, we set out a framework for expanding outcome...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
Elsevier,
2024-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | How do we assess the overall benefit and value of GLP1-RAs? Current clinical trials often focus narrowly on individual atherosclerotic cardiovascular endpoints like MACE, potentially missing broader GLP-1 RA benefits across multiple comorbidities. Herein, we set out a framework for expanding outcome analyses in large trials that we believe will provide a more holistic understanding of GLP-1 RA benefits across the cardio-kidney-metabolic (CKM) spectrum, guiding patient care, guidelines, and insurance coverage decisions. |
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| Item Description: | 2666-6677 10.1016/j.ajpc.2024.100682 |