Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria <i>Bacillus</i> sp. BO53 and <i>Pseudoalteromonas</i> sp. GA327
The present research aimed to evaluate the antibacterial activity of volatile organic compounds (VOCs) produced by octocoral-associated bacteria <i>Bacillus</i> sp. BO53 and <i>Pseudoalteromonas</i> sp. GA327. The volatilome bioactivity of both bacteria species was evaluated...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2020-12-01T00:00:00Z.
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| Summary: | The present research aimed to evaluate the antibacterial activity of volatile organic compounds (VOCs) produced by octocoral-associated bacteria <i>Bacillus</i> sp. BO53 and <i>Pseudoalteromonas</i> sp. GA327. The volatilome bioactivity of both bacteria species was evaluated against human pathogenic antibiotic-resistant bacteria, methicillin-resistant <i>Staphylococcus aureus</i>, <i>Acinetobacter baumanni</i>, and <i>Pseudomonas aeruginosa</i>. In this regard, the in vitro tests showed that <i>Bacillus</i> sp. BO53 VOCs inhibited the growth of <i>P. aeruginosa</i> and reduced the growth of <i>S. aureus</i> and <i>A. baumanni</i>. Furthermore, <i>Pseudoalteromonas</i> sp. GA327 strongly inhibited the growth of <i>A. baumanni</i>, and <i>P. aeruginosa</i>. VOCs were analyzed by headspace solid-phase microextraction (HS-SPME) joined to gas chromatography-mass spectrometry (GC-MS) methodology. Nineteen VOCs were identified, where 5-acetyl-2-methylpyridine, 2-butanone, and 2-nonanone were the major compounds identified on <i>Bacillus</i> sp. BO53 VOCs; while 1-pentanol, 2-butanone, and butyl formate were the primary volatile compounds detected in <i>Pseudoalteromonas</i> sp. GA327. We proposed that the observed bioactivity is mainly due to the efficient inhibitory biochemical mechanisms of alcohols and ketones upon antibiotic-resistant bacteria. This is the first report which describes the antibacterial activity of VOCs emitted by octocoral-associated bacteria. |
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| Item Description: | 10.3390/antibiotics9120923 2079-6382 |