24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer's Disease

• Príomhchruthaitheoirí: Gabriella Testa (Údar), Serena Giannelli (Údar), Barbara Sottero (Údar), Erica Staurenghi (Údar), Giorgio Giaccone (Údar), Paola Caroppo (Údar), Paola Gamba (Údar), Gabriella Leonarduzzi (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2023-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer's disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-hydroxycholesterol (24-OHC) has recently...