A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
<p>Abstract</p> <p>Background</p> <p>Therapeutic biologic agents are uncommonly associated with lymphoma.</p> <p>Case presentation</p> <p>We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva<sup>®</sup&...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
BMC,
2008-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Therapeutic biologic agents are uncommonly associated with lymphoma.</p> <p>Case presentation</p> <p>We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva<sup>®</sup>) and etanercept (Enbrel<sup>®</sup>), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymphoma clinically and pathologically. Lymphocytosis and lymphadenopathy spontaneously remitted following cessation of etanercept therapy and have not recurred.</p> <p>Conclusion</p> <p>Distinction between clinically benign lymphoid proliferations related to antipsoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy.</p> |
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| Item Description: | 10.1186/1746-1596-3-13 1746-1596 |