Evaluation of the Ability of Immune Humanized Mice to Demonstrate CD20‐Specific Cytotoxicity Induced by Ofatumumab

• Main Authors: Kenrick M. Semple (Author), Carlos M. Gonzaléz (Author), Melissa Zarr (Author), José R. Austin (Author), Vikram Patel (Author), Kristina E. Howard (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD20 monoclonal antibodies are well‐established therapeutics for the treatment of B‐cell malignancies. Several mechanisms of target cell killing occur from anti‐CD20 therapy, including complement‐dependent cytotoxicity (CDC) cell lysis and antibody‐dependent cell‐mediated cytotoxicity. Human Fc rece...