Forefront of Na+/Ca2+ Exchanger Studies: Physiology and Molecular Biology of Monovalent Cation Sensitivities in Na+/Ca2+ Exchangers
Sensitivities of the reverse-mode Na+/Ca2+ exchange activity measured as the Na+i-dependent Ca2+ uptake to extracellular monovalent cations K+, Li+, and Na+ were compared between the K+-dependent (NCKX2) and the K+-independent Na+/Ca2+ exchanger (NCX1) overexpressed in a fibroblast cell. Interesting...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2004-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_421cada8dc2049d1a06caab36b0d5ad3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Akira Uehara |e author |
| 700 | 1 | 0 | |a Takahiro Iwamoto |e author |
| 700 | 1 | 0 | |a Yuki Nakamura |e author |
| 700 | 1 | 0 | |a Issei Imanaga |e author |
| 245 | 0 | 0 | |a Forefront of Na+/Ca2+ Exchanger Studies: Physiology and Molecular Biology of Monovalent Cation Sensitivities in Na+/Ca2+ Exchangers |
| 260 | |b Elsevier, |c 2004-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.fmj04002x4 | ||
| 520 | |a Sensitivities of the reverse-mode Na+/Ca2+ exchange activity measured as the Na+i-dependent Ca2+ uptake to extracellular monovalent cations K+, Li+, and Na+ were compared between the K+-dependent (NCKX2) and the K+-independent Na+/Ca2+ exchanger (NCX1) overexpressed in a fibroblast cell. Interestingly, the exchange activity of NCKX2 was not influenced by Li+ while it was increased by K+. On the contrary, the activity of NCX1 was increased by Li+. Thus, the cation sensitivities to K+ and Li+ markedly differed between NCKX2 and NCX1. In addition, Na+ exerted a significantly smaller inhibitory effect on the activity in NCKX2 than in NCX1. The Na+/Ca2+ exchange activities of NCKX2 and NCX1 are considered to be regulated differentially via the respective binding site domains that have distinct sensitivities to the external monovalent cations. Keywords:: Na+/Ca2+ exchanger (NCX), K+-dependent NCX (NCKX)2, NCX1 | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 96, Iss 1, Pp 19-22 (2004) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319323722 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/421cada8dc2049d1a06caab36b0d5ad3 |z Connect to this object online. |