A Retrospective Database Analysis to Estimate the Burden of Acute Otitis Media in Children Aged <15 Years in the Veneto Region (Italy)
This study aimed to assess trends in the incidence of acute otitis media (AOM), a common childhood condition, following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in the Veneto region of Italy in 2010. AOM episodes (overall, simple, and recurrent (≥3 or ≥4 episodes in 6...
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MDPI AG,
2022-03-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_42aeb8ff139c4d70a716f84b3e58f6d2 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Elisa Barbieri |e author |
| 700 | 1 | 0 | |a Gloria Porcu |e author |
| 700 | 1 | 0 | |a Tianyan Hu |e author |
| 700 | 1 | 0 | |a Tanaz Petigara |e author |
| 700 | 1 | 0 | |a Francesca Senese |e author |
| 700 | 1 | 0 | |a Gian Marco Prandi |e author |
| 700 | 1 | 0 | |a Antonio Scamarcia |e author |
| 700 | 1 | 0 | |a Luigi Cantarutti |e author |
| 700 | 1 | 0 | |a Anna Cantarutti |e author |
| 700 | 1 | 0 | |a Carlo Giaquinto |e author |
| 245 | 0 | 0 | |a A Retrospective Database Analysis to Estimate the Burden of Acute Otitis Media in Children Aged <15 Years in the Veneto Region (Italy) |
| 260 | |b MDPI AG, |c 2022-03-01T00:00:00Z. | ||
| 500 | |a 10.3390/children9030436 | ||
| 500 | |a 2227-9067 | ||
| 520 | |a This study aimed to assess trends in the incidence of acute otitis media (AOM), a common childhood condition, following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in the Veneto region of Italy in 2010. AOM episodes (overall, simple, and recurrent (≥3 or ≥4 episodes in 6 or 12 months, respectively, with ≥1 episode in the preceding 6 months)) in children <15 years of age were identified in Pedianet from 2010-2017. Interrupted time series analyses were conducted to assess changes in the annual incidence rates (IRs) in early (2010-2013) and late (2014-2017) PCV13 periods. In total, 72,570 children (402,868 person-years) were identified; 21,048 had 41,683 AOM episodes. Mean annual AOM IR was 103/1000 person-years (95% confidence interval: 102-104), decreasing from 126 to 79/1000 person-years. AOM IRs were highest in children 2-4 years of age, followed by <2 and 5-14 years of age. Overall and simple AOM IRs decreased among children 0-14 years of age, including 2-4 and 5-14 years of age, while recurrent AOM IRs decreased in children <2 years of age. Following PCV13 introduction, AOM IRs decreased substantially in children <15 years of age, with the greatest benefit observed in older children, driven by a reduction in simple AOM IRs. AOM disease burden remains substantial. | ||
| 546 | |a EN | ||
| 690 | |a acute otitis media | ||
| 690 | |a recurrent acute otitis media | ||
| 690 | |a incidence | ||
| 690 | |a pneumococcal vaccination | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Children, Vol 9, Iss 3, p 436 (2022) | |
| 787 | 0 | |n https://www.mdpi.com/2227-9067/9/3/436 | |
| 787 | 0 | |n https://doaj.org/toc/2227-9067 | |
| 856 | 4 | 1 | |u https://doaj.org/article/42aeb8ff139c4d70a716f84b3e58f6d2 |z Connect to this object online. |