Pinostrobin inhibits renal CFTR-mediated Cl− secretion and retards cyst growth in cell-derived cyst and polycystic kidney disease rats

• Autori principali: Kanlayanee Tonum (Autore), Napason Chabang (Autore), Somsak Fongsupa (Autore), Suphat Chantawarin (Autore), Chutima Jiarpinitnun (Autore), Patoomrattana Tuchinda (Autore), Sunhapas Soodvilai (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Cystic fibrosis transmembrane conductance regulator (CFTR) plays crucial role in renal cyst expansion via increase in fluid accumulation. Inhibition of CFTR has been proposed to retard cyst development and enlargement in polycystic kidney disease (PKD). Pinostrobin, a bioactive natural flavonoid, po...