Transient Transfection of the Respiratory Epithelium with Gamma Interferon for Host-Directed Therapy in Pulmonary Tuberculosis

• Main Authors: Reena Bharti (Author), Ashish Srivastava (Author), Trisha Roy (Author), Khushboo Verma (Author), D.V. Siva Reddy (Author), Hasham Shafi (Author), Sonia Verma (Author), Sunil K. Raman (Author), Amit K. Singh (Author), Jyotsna Singh (Author), Lipika Ray (Author), Amit Misra (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nebulized gamma interferon (IFN-γ) protein has been studied for clinical safety and efficacy against pulmonary tuberculosis (TB). The protein is expensive, requires a cold chain, and is difficult to deploy in limited-resource, high-incidence settings. We generated a preclinical proof of concept (PoC...