Transient Transfection of the Respiratory Epithelium with Gamma Interferon for Host-Directed Therapy in Pulmonary Tuberculosis

• मुख्य लेखकों: Reena Bharti (लेखक), Ashish Srivastava (लेखक), Trisha Roy (लेखक), Khushboo Verma (लेखक), D.V. Siva Reddy (लेखक), Hasham Shafi (लेखक), Sonia Verma (लेखक), Sunil K. Raman (लेखक), Amit K. Singh (लेखक), Jyotsna Singh (लेखक), Lipika Ray (लेखक), Amit Misra (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Nebulized gamma interferon (IFN-γ) protein has been studied for clinical safety and efficacy against pulmonary tuberculosis (TB). The protein is expensive, requires a cold chain, and is difficult to deploy in limited-resource, high-incidence settings. We generated a preclinical proof of concept (PoC...