A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction

• Main Authors: Elizabeth A. Killion (Author), Andrew R. Reeves (Author), Mahmoud A. El Azzouny (Author), Qing-Wu Yan (Author), Defne Surujon (Author), John D. Griffin (Author), Thomas A. Bowman (Author), Chunyan Wang (Author), Nirupa R. Matthan (Author), Eric L. Klett (Author), Dong Kong (Author), John W. Newman (Author), Xianlin Han (Author), Mi-Jeong Lee (Author), Rosalind A. Coleman (Author), Andrew S. Greenberg (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo act...