EXPERIENCE OF SEVERE SYSTEM TYPE OF JUVENILE RHEUMATOID ARTHRITIS TREATMENT WITH CYCLOSPORINE IN COMBINATION WITH DIFFERENT METHOTREXATE REGIMEN

• Main Authors: T.M. Bzarova (Author), E.I. Alexeeva (Author), S.I. Valieva (Author), A.O. Lisitsin (Author)
• Format: Book
• Published: "Paediatrician" Publishers LLC, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<em>The article presents the case report of early debut and severe course of system type of juvenile rheumatoid arthritis, refractory to methotrexate and blockers of tumor necrotizing factor _ monotherapy. Successful treatment with cyclosporine in daily dose 4.4 mg/kg of body weight combined with different regimen of methotrexate was described. Combined treatment with cyclosporine in daily dose 4.4 mg/kg of body weight and methotrexate in dose 15 mg/m2 of body surface once weekly intramuscularly and 50 mg/m2 of body surface once weekly intravenously during 8 weeks with further dose decrease to 25 mg/m2 of body surface intramuscularly induced remission development in 2-6 months, provided restoration of joints function, increased quality of life. Cyclosporine combined with pulse-therapy with methotrexate in more early stages stopped extra articulate signs of disease and reduced acute inflammatory joint's lesions.</em><br /><strong><em>Key words: children, juvenile rheumatoid arthritis, cyclosporine, methotrexate.</em></strong><br /><span style="text-decoration: underline;"><em>(<em><em><em>Voprosy sovremennoi pediatrii - </em></em></em>Current Pediatrics. 2009;8(4):<em>142-150</em>)</em></span>

Item Description

1682-5527
1682-5535