Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL/6J mice by activating the BDNF/TrkB pathway

• Main Authors: Jiahao Dong (Author), Ran Wei (Author), Fangjiao Zong (Author), Zhe Wang (Author), Shengyao Ma (Author), Wei Zhao (Author), Yuanyuan Lin (Author), Aixin Zhang (Author), Ge Lan (Author), Fang Zhang (Author), Han-Ting Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundPhosphodiesterase 7 (PDE7) plays a role in neurological function. Increased expression and activity of PDE7 has been detected in several central nervous system diseases. However, the role of PDE7 in regulating stress levels remains unclear. Thus, this study aimed to determine whether and h...