Rational design of heat stable lyophilized rotavirus vaccine formulations

• Ngā kaituhi matua: Madhu Madan (Author), Deepa Sikriwal (Author), Gaurav Sharma (Author), Nidhi Shukla (Author), Ashwani Kumar Mandyal (Author), Sachin Kale (Author), Davinder Gill (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2018-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

To develop a safe and efficacious heat-stable rotavirus vaccine, new lyophilized formulations were developed using rotavirus serotypes constituting RotaTeq®. A series of formulation compositions, differing in buffering agents, bulking agents, cryoprotectants, amino acids and divalent cations, were s...