Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

• Main Authors: Tatevik Ohanyan (Author), Nicole Schoepke (Author), Stefan Eirefelt (Author), Gert Hoey (Author), Witte Koopmann (Author), Tomasz Hawro (Author), Marcus Maurer (Author), Martin Metz (Author)
• Format: Book
• Published: Medical Journals Sweden, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increas...