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A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis

Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathw...

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Main Authors: Elvira Umyarova MD (Author), Sreedhar Adapa MD (Author), Srikanth Naramala MD (Author), Vijay Gayam MD (Author), Narothama Reddy Aeddula MD (Author), Venu Madhav Konala MD (Author)
Format: Book
Published: SAGE Publishing, 2019-06-01T00:00:00Z.
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Summary:Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis.
Item Description:2324-7096
10.1177/2324709619858643

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