PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration

• Principais autores: Sheri L. Peterson (Autor), Anitha Krishnan (Autor), Diyan Patel (Autor), Ali Khanehzar (Autor), Amit Lad (Autor), Jutamas Shaughnessy (Autor), Sanjay Ram (Autor), David Callanan (Autor), Derek Kunimoto (Autor), Mohamed A. Genead (Autor), Michael J. Tolentino (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2024-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, while effective, have clinically observed risks of...