Precocious puberty in a patient with Oculo-Auriculo-Verebral spectrum (OAVS)
The authors report on the first case of OAVS (Oculo-Auriculo- Vertebral-Spectrum), with hemifacial microsomy, hydrocephalus, pubertas precox, thelarche at 4 years of age, vaginal bleeding at 5 years, and left ovary of adult type on echography (right ovary initially not visualized). FISH and CGH-ARRA...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
PAGEPress Publications,
2014-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The authors report on the first case of OAVS (Oculo-Auriculo- Vertebral-Spectrum), with hemifacial microsomy, hydrocephalus, pubertas precox, thelarche at 4 years of age, vaginal bleeding at 5 years, and left ovary of adult type on echography (right ovary initially not visualized). FISH and CGH-ARRAYS methods were negative. By GnRH therapy the delay of onset puberty was obtained. The authors ascribe facial and ovary asymmetry to a derangement of blastogenesis, during which axial right-left structures begin the develop with consequent migration or interation with surrounding tissues of neural crest cells and alteration of diencephalic pituitary systems. |
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| Item Description: | 10.4081/pmc.2014.11 0391-5387 2420-7748 |