New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling

• Egile Nagusiak: Alba Vicente-Blázquez (Egilea), Myriam González (Egilea), Manuel Medarde (Egilea), Faustino Mollinedo (Egilea), Rafael Peláez (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or the indole 3-position were synthesised. They show submicromolar to nanomolar antiproliferative IC50 values against four human tumour cell line...