A randomized cross over trial of tolerability and compliance of a micronutrient supplement with low iron separated from calcium vs high iron combined with calcium in pregnant women [ISRCTN56071145]
<p>Abstract</p> <p>Background</p> <p>Prenatal micronutrient combinations with high iron content are associated with high rates of gastrointestinal symptoms. This coupled with nausea and vomiting of pregnancy results in women often discontinuing their multivitamins.</...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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BMC,
2006-04-01T00:00:00Z.
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Prenatal micronutrient combinations with high iron content are associated with high rates of gastrointestinal symptoms. This coupled with nausea and vomiting of pregnancy results in women often discontinuing their multivitamins.</p> <p>A new prescription supplement (PregVit<sup>®</sup>) that separates iron from calcium in two tablets - morning and evening, has lower elemental iron content (35 mg), but results in similar extent of iron absorption when compared to another supplement containing (60 mg) of elemental iron (Materna<sup>®</sup>). The objectives of this study were to compare tolerability and compliance with PregVit<sup>® </sup>vs. a supplement with high iron content (Materna<sup>®</sup>), in pregnant women.</p> <p>Methods</p> <p>Randomized, crossover open labeled study in 135 pregnant women attending outpatient clinics in Ontario and Quebec.</p> <p>Results</p> <p>Use of PregVit<sup>® </sup>was associated with a 30% reduction in constipation rate as compared to Materna<sup>®</sup>. Both products demonstrated similar compliance rates.</p> <p>Compliance of Materna<sup>® </sup>was negatively associated with the severity of nausea and vomiting of pregnancy. No such correlation was found for PregVvit<sup>®</sup>.</p> <p>Conclusion</p> <p>PregVit<sup>®</sup>, a supplement with lower iron content (35 mg), has significantly decreased constipation rates as compared to 60 mg iron- Materna and has similar compliance rates. High iron content in multivitamin supplements is associated with adverse effects in pregnancy.</p> |
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| Item Description: | 10.1186/1471-2393-6-10 1471-2393 |