Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

• Main Authors: Chun Chu (Author), Ping Xu (Author), Haoyue Zhao (Author), Qing Chen (Author), Dawei Chen (Author), Haiyang Hu (Author), Xiuli Zhao (Author), Mingxi Qiao (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Various biotin-modified liposomes incorporated with docetaxel (DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome (PDL), 0.5% (mol) biotin modified liposome (0.5BDL), 1% (mol) biotin m...