Cover Image

Localization of <sup>99m</sup>Tc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

The overexpression of gastrin-releasing peptide receptors (GRPRs) in frequently occurring human tumors has provided the opportunity to use bombesin (BBN) analogs as radionuclide carriers to cancer sites for diagnostic and therapeutic purposes. We have been alternatively exploring human GRP motifs of...

Full description

Saved in:

Bibliographic Details
Main Authors:	Aikaterini Kaloudi (Author), Emmanouil Lymperis (Author), Panagiotis Kanellopoulos (Author), Beatrice Waser (Author), Marion de Jong (Author), Eric P. Krenning (Author), Jean Claude Reubi (Author), Berthold A. Nock (Author), Theodosia Maina (Author)
Format:	Book
Published:	MDPI AG, 2019-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [<sup>99m</sup>Tc]Tc-DB4 and [<sup>111</sup>In]In-SG4 in Mice Treated with Entresto
by: Panagiotis Kanellopoulos, et al.
Published: (2020)

Toward Stability Enhancement of NTS<sub>1</sub>R-Targeted Radioligands: Structural Interventions on [<sup>99m</sup>Tc]Tc-DT1
by: Panagiotis Kanellopoulos, et al.
Published: (2023)

Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands
by: Panagiotis Kanellopoulos, et al.
Published: (2020)

Preclinical Evaluation of <sup>99m</sup>Tc-Labeled GRPR Antagonists maSSS/SES-PEG<sub>2</sub>-RM26 for Imaging of Prostate Cancer
by: Ayman Abouzayed, et al.
Published: (2021)

Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
by: Panagiotis Kanellopoulos, et al.
Published: (2024)

GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
by: Karim Obeid, et al.
Published: (2024)

[<sup>111</sup>In]In/[<sup>177</sup>Lu]Lu-AAZTA<sup>5</sup>-LM4 SST<sub>2</sub>R-Antagonists in Cancer Theranostics: From Preclinical Testing to First Patient Results
by: Berthold A. Nock, et al.
Published: (2023)

Radiosynthesis and Preclinical Evaluation of [<sup>99m</sup>Tc]Tc-Tigecycline Radiopharmaceutical to Diagnose Bacterial Infections
by: Syeda Marab Saleem, et al.
Published: (2024)

Synthesis and Biodistribution of <sup>99m</sup>Tc-Labeled PLGA Nanoparticles by Microfluidic Technique
by: Michela Varani, et al.
Published: (2021)

[<sup>99m</sup>Tc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging
by: Jiali Gong, et al.
Published: (2022)

In Vitro Hemocompatibility and Genotoxicity Evaluation of Dual-Labeled [<sup>99m</sup>Tc]Tc-FITC-Silk Fibroin Nanoparticles for Biomedical Applications
by: María Alejandra Asensio Ruiz, et al.
Published: (2023)

Initial Experience of Clinical Use of [<sup>99m</sup>Tc]Tc-PSMA-T4 in Patients with Prostate Cancer. A Pilot Study
by: Jarosław B. Ćwikła, et al.
Published: (2021)

Phase I Clinical Trial Using [<sup>99m</sup>Tc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients
by: Vladimir Chernov, et al.
Published: (2022)

Different PSMA Radiopharmaceuticals: A Comparative Study of [<sup>18</sup>F]F-PSMA-1007, [<sup>18</sup>F]F-JK-PSMA-7, and [<sup>99m</sup>Tc]Tc-PSMA-I&S in the Skeletal System
by: Zsófia Sára Mikó, et al.
Published: (2024)

<sup>99m</sup>Tc-Labeled FAPI SPECT Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results
by: Yu Liu, et al.
Published: (2023)

Inhibition of the Hepatic Uptake of <sup>99m</sup>Tc-Tetrofosmin Using an Organic Cation Transporter Blocker
by: Kodai Nishi, et al.
Published: (2021)

Radiolabeling and Biological Evaluation of Novel <sup>99m</sup>Tc-Nitrido and <sup>99m</sup>Tc-Oxo Complexes with 4-Methoxy-<sub><span style="font-variant: small-caps">L</span></sub>-Phenylalanine Dithiocarbamate for Tumor Imaging
by: Guangxing Yin, et al.
Published: (2022)

[<sup>99m</sup>Tc]Tc-iFAP Radioligand for SPECT/CT Imaging of the Tumor Microenvironment: Kinetics, Radiation Dosimetry, and Imaging in Patients
by: Luis Coria-Domínguez, et al.
Published: (2022)

Optimization of the Pharmacokinetic Profile of [<sup>99m</sup>Tc]Tc-N<sub>4</sub>-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
by: Thomas Günther, et al.
Published: (2022)

[<sup>99m</sup>Tc]Tc-iFAP/SPECT Tumor Stroma Imaging: Acquisition and Analysis of Clinical Images in Six Different Cancer Entities
by: Paola Vallejo-Armenta, et al.
Published: (2022)

The role of digital mammography, scintimammography with <sup>99m </sup>Tc-methoxyisobutylisonitrile (MIBI) and ultrasound in the diagnosis of multicentric breast cancer
by: A. V. Chernaya, et al.
Published: (2020)

Synthesis and Evaluation of <sup>99m</sup>Tc(CO)<sub>3</sub> Complexes with Ciprofloxacin Dithiocarbamate for Infection Imaging
by: Afroditi Papasavva, et al.
Published: (2024)

Synthesis and Evaluation of <sup>99m</sup>Tc-Labelled 2-Nitroimidazole Derivatives with Different Linkers for Tumour Hypoxia Imaging
by: Qing Ruan, et al.
Published: (2023)

Synthesis and Evaluation of Novel Norfloxacin Isonitrile <sup>99m</sup>Tc Complexes as Potential Bacterial Infection Imaging Agents
by: Si'an Fang, et al.
Published: (2021)

Imaging-Based Characterization of a <i>Slco2b1<sup>(-/-)</sup></i> Mouse Model Using [<sup>11</sup>C]Erlotinib and [<sup>99m</sup>Tc]Mebrofenin as Probe Substrates
by: Solène Marie, et al.
Published: (2021)

Evaluation of Approaches for the Assessment of HER2 Expression in Breast Cancer by Radionuclide Imaging Using the Scaffold Protein [<sup>99m</sup>Tc]Tc-ADAPT6
by: Olga Bragina, et al.
Published: (2024)

Pharmacokinetic Imaging Using <sup>99m</sup>Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
by: Solène Marie, et al.
Published: (2022)

<sup>99m</sup>Tc-Labeled Cyclic Peptide Targeting PD-L1 as a Novel Nuclear Imaging Probe
by: Guillermina Ferro-Flores, et al.
Published: (2023)

Preparation and Bioevaluation of Novel <sup>99m</sup>Tc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia
by: Qing Ruan, et al.
Published: (2021)

Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [<sup>99m</sup>Tc]mebrofenin Imaging in Rats
by: Solène Marie, et al.
Published: (2020)

Preparation and Bioevaluation of a Novel <sup>99m</sup>Tc-Labeled Glucose Derivative Containing Cyclohexane as a Promising Tumor Imaging Agent
by: Junhong Feng, et al.
Published: (2023)

SPECT Imaging of SST2-Expressing Tumors with <sup>99m</sup>Tc-Based Somatostatin Receptor Antagonists: The Role of Tetraamine, HYNIC, and Spacers
by: Raghuvir Haridas Gaonkar, et al.
Published: (2021)

Comparative Evaluation of Radiochemical and Biological Properties of <sup>131</sup>I- and [<sup>99m</sup>Tc]Tc(CO)<sub>3</sub>-Labeled RGD Analogues Planned to Interact with the α<sub>v</sub>β<sub>3</sub> Integrin Expressed in Glioblastoma
by: Danielle V. Sobral, et al.
Published: (2022)

Diagnosis of Prostate Cancer with a Neurotensin-Bombesin Radioligand Combination-First Preclinical Results
by: Maria Bibika, et al.
Published: (2024)

Automated Synthesis of [<sup>68</sup>Ga]Ga-FAPI-46 on a Scintomics GRP Synthesizer
by: Elisabeth Plhak, et al.
Published: (2023)

Development of the <sup>99m</sup>Tc-Labelled SST<sub>2</sub> Antagonist TECANT-1 for a First-in-Man Multicentre Clinical Study
by: Doroteja Novak, et al.
Published: (2023)

Selection of the First <sup>99m</sup>Tc-Labelled Somatostatin Receptor Subtype 2 Antagonist for Clinical Translation-Preclinical Assessment of Two Optimized Candidates
by: Melpomeni Fani, et al.
Published: (2020)

Peptide Radioligands in Cancer Theranostics: Agonists and Antagonists
by: Berthold A. Nock, et al.
Published: (2023)

Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase
by: Kevin R. Doornhof, et al.
Published: (2024)

Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK<sub>2</sub>R Cancer Theranostic Agents: A Preclinical Study
by: Berthold A. Nock, et al.
Published: (2022)