Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study

• Main Authors: Laurent Orsi (Author), Patricia Margaritte-Jeannin (Author), Miora Andrianjafimasy (Author), Orianne Dumas (Author), Hamida Mohamdi (Author), Emmanuelle Bouzigon (Author), Florence Demenais (Author), Régis Matran (Author), Farid Zerimech (Author), Rachel Nadif (Author), Marie-Hélène Dizier (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Oxidative stress (OS) is the main pathophysiological mechanism involved in several chronic diseases, including asthma. Fluorescent oxidation products (FlOPs), a global biomarker of damage due to OS, is of growing interest in epidemiological studies. We conducted a genome-wide association study (GWAS) of the FlOPs level in 1216 adults from the case-control and family-based EGEA study (mean age 43 years old, 51% women, and 23% current smokers) to identify genetic variants associated with FlOPs. The GWAS was first conducted in the whole sample and then stratified according to smoking status, the main exogenous source of reactive oxygen species. Among the top genetic variants identified by the three GWAS, those located in <i>BMP6</i> (<i>p</i> = 3 <span style="font-variant: small-caps;">×</span> 10⁻⁶), near <i>BMPER</i> (<i>p</i> = 9 <span style="font-variant: small-caps;">×</span> 10⁻⁶), in <i>GABRG3</i> (<i>p</i> = 4 <span style="font-variant: small-caps;">×</span> 10⁻⁷), and near <i>ATG5</i> (<i>p</i> = 2 <span style="font-variant: small-caps;">×</span> 10⁻⁹) are the most relevant because of both their link to biological pathways related to OS and their association with several chronic diseases for which the role of OS in their pathophysiology has been pointed out. <i>BMP6</i> and <i>BMPER</i> are of particular interest due to their involvement in the same biological pathways related to OS and their functional interaction. To conclude, this study, which is the first GWAS of FlOPs, provides new insights into the pathophysiology of chronic OS-related diseases.

Item Description

10.3390/antiox11050802
2076-3921