Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis

• Main Authors: Aateka Patel (Author), Ewelina Hoffman (Author), Doug Ball (Author), Jan Klapwijk (Author), Rory T. Steven (Author), Alex Dexter (Author), Josephine Bunch (Author), Daniel Baker (Author), Darragh Murnane (Author), Victoria Hutter (Author), Clive Page (Author), Lea Ann Dailey (Author), Ben Forbes (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is currently used as a model of pulmo...