Malondialdehyde Levels in Preeclampsia before and after Delivery

• Main Authors: Harold Rumopa (Author), Freddy W. Wagey (Author), Eddy Suparman (Author)
• Format: Book
• Published: Indonesian Society of Obstetrics and Gynecology, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: Determine differences plasma levels MDA in preeclampsia before and 2 hours after delivery.   Methods: This was an analytic cross-sectional study. Subject consists of 23 pregnancies with preeclampsia, where 23 blood samples taken before delivery and 23 were taken 2 hours after delivery. This study was conducted from August 2016 until December 2016 at Department of Obstetrics and Gynecology Faculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D. Kandou Hospital Manado and satellite hospital. Samples were taken from plasma and analysed using HPLC method at Prodia clinical laboratory.   Results: In patients with severe preeclampsia before delivery we found average value (1.4796 ï,± 0.40819 nmol/ml), minimum value (1.03 nmol/ml) and maximal value (2.77 nmol/ml) and 2 hours after delivery with average value (1.2470 ï,± 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximum value (2.47 nmol/ml). by using Wilcoxon test, we found there were significant differences in plasma levels of MDA (p = 0.000).   Conclusion: This significant difference suggests that decreased plasma levels of MDA 2 hours after delivery and gives the sense that there is a relationship between oxidative stress of cells with severe preeclampsia before and shortly after delivery, that MDA is an indicator of oxidative stress.   Keywords: malondialdehyde, oxidative stress, peroxidation lipid, preeclampsia

Item Description

2338-6401
2338-7335
10.32771/inajog.v6i3.777