Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling

• Autori principali: Nan-Hung Hsieh (Autore), Brad Reisfeld (Autore), Frederic Y. Bois (Autore), Weihsueh A. Chiu (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Traditionally, the solution to reduce parameter dimensionality in a physiologically-based pharmacokinetic (PBPK) model is through expert judgment. However, this approach may lead to bias in parameter estimates and model predictions if important parameters are fixed at uncertain or inappropriate valu...