DNA Damage Response Pathway and Replication Fork Stress During Oligonucleotide Directed Gene Editing

• Principais autores: Melissa Bonner (Autor), Bryan Strouse (Autor), Mindy Applegate (Autor), Paula Livingston (Autor), Eric B Kmiec (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2012-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Single-stranded DNA oligonucleotides (ODNs) can be used to direct the exchange of nucleotides in the genome of mammalian cells in a process known as gene editing. Once refined, gene editing should become a viable option for gene therapy and molecular medicine. Gene editing is regulated by a number o...