Statistical analysis of single-copy assays when some observations are zero

• Main Authors: Peter Bacchetti (Author), Ronald J. Bosch (Author), Eileen P. Scully (Author), Xutao Deng (Author), Michael P. Busch (Author), Steven G. Deeks (Author), Sharon R. Lewin (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Observational and interventional studies for HIV cure research often use single-copy assays to quantify rare entities in blood or tissue samples. Statistical analysis of such measurements presents challenges due to tissue sampling variability and frequent findings of 0 copies in the sample analysed....