Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators

• Main Authors: Larisa H. Cavallari (Author), Emily Cicali (Author), Kristin Wiisanen (Author), Roger B. Fillingim (Author), Hrishikesh Chakraborty (Author), Rachel A. Myers (Author), Kathryn V. Blake (Author), Bolanle Asiyanbola (Author), Jordan F. Baye (Author), Wesley H. Bronson (Author), Kelsey J. Cook (Author), Erica N. Elwood (Author), Chancellor F. Gray (Author), Yan Gong (Author), Lindsay Hines (Author), Joseph Kannry (Author), Natalie Kucher (Author), Sheryl Lynch (Author), Khoa A. Nguyen (Author), Aniwaa Owusu Obeng (Author), Victoria M. Pratt (Author), Hernan A. Prieto (Author), Michelle Ramos (Author), Azita Sadeghpour (Author), Rajbir Singh (Author), Marc Rosenman (Author), Petr Starostik (Author), Cameron D. Thomas (Author), Emma Tillman (Author), Paul R. Dexter (Author), Carol R. Horowitz (Author), Lori A. Orlando (Author), Josh F. Peterson (Author), Todd C. Skaar (Author), Sara L. Van Driest (Author), Simona Volpi (Author), Deepak Voora (Author), Hari K. Parvataneni (Author), Julie A. Johnson (Author), for the IGNITE Pragmatic Trials Network (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Opioid prescribing for postoperative pain management is challenging because of inter‐patient variability in opioid response and concern about opioid addiction. Tramadol, hydrocodone, and codeine depend on the cytochrome P450 2D6 (CYP2D6) enzyme for formation of highly potent metabolites. In...