Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.

• Main Authors: Dimitri Bulté (Author), Lieselotte Van Bockstal (Author), Laura Dirkx (Author), Magali Van den Kerkhof (Author), Carl De Trez (Author), Jean-Pierre Timmermans (Author), Sarah Hendrickx (Author), Louis Maes (Author), Guy Caljon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutati...