Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.

• Главные авторы: Dimitri Bulté (Автор), Lieselotte Van Bockstal (Автор), Laura Dirkx (Автор), Magali Van den Kerkhof (Автор), Carl De Trez (Автор), Jean-Pierre Timmermans (Автор), Sarah Hendrickx (Автор), Louis Maes (Автор), Guy Caljon (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Предметы: article
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<h4>Background</h4>Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutati...