Identification of Antioxidant Metabolites from Five Plants (<i>Calophyllum inophyllum</i>, <i>Gardenia taitensis</i>, <i>Curcuma longa</i>, <i>Cordia subcordata</i>, <i>Ficus prolixa</i>) of the Polynesian Pharmacopoeia and Cosmetopoeia for Skin Care

• Main Authors: Marion Chambon (Author), Raimana Ho (Author), Beatrice Baghdikian (Author), Gaëtan Herbette (Author), Sok-Si (Author), Elnur Garayev (Author), Phila Raharivelomanana (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antiox12101870; 2076-3921
• Keywords: <i>Calophyllum inophyllum</i>; <i>Gardenia taitensis</i>; <i>Curcuma longa</i>; <i>Cordia subcordata</i>; <i>Ficus prolixa</i>; French Polynesia; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 12, Iss 10, p 1870 (2023)

Oxidative stress contributes to impairment of skin health, the wound healing process, and pathologies such as psoriasis or skin cancer. Five Polynesian medicinal plants, among the most traditionally used for skin care (pimples, wounds, burns, dermatoses) are studied herein for their antioxidant properties: <i>Calophyllum inophyllum</i>, <i>Gardenia taitensis</i>, <i>Curcuma longa</i>, <i>Cordia subcordata</i>, and <i>Ficus prolixa</i>. Plant extracts were submitted to in vitro bioassays related to antioxidant properties and their bioactive constituents were identified by a metabolomic analytical approach. High performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) analysis was performed leading to the characterization of 61 metabolites. Compounds annotated for <i>F. prolixa</i> and <i>C. subcordata</i> extracts were reported for the first time. Antioxidant properties were evaluated by total phenolic content (TPC), free radical scavenging DPPH (1,1-diphenyl-2-picryl-hydrazyl), and Ferric Reducing Antioxidant Power activity (FRAP) assays. <i>F. prolixa</i> extract was the most active one and showed antioxidant intracellular activity on keratinocytes by Anti Oxydant Power 1 assay. Online HPLC-DPPH allowed the identification of phenolic bioactive compounds such as quercetin-<i>O</i>-rhamnoside, rosmarinic acid, chlorogenic acid, procyanidins, epicatechin, 5-<i>O</i>-caffeoylshikimic acid, and curcumin as being responsible for the scavenging properties of these plant extracts. These results highlight the potential of <i>F. prolixa</i> aerial roots as a source of antioxidants for skin care applications.