The Bioactivity of D-/L-Isonucleoside- and 2'-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression

• Main Authors: Xinmeng Fan (Author), Lidan Sun (Author), Kunfeng Li (Author), Xiantao Yang (Author), Baobin Cai (Author), Yanfen Zhang (Author), Yuejie Zhu (Author), Yuan Ma (Author), Zhu Guan (Author), Yun Wu (Author), Lihe Zhang (Author), Zhenjun Yang (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, chemical modification of 2'-deoxyinosine (2'-dI) and D-/L-isothymidine (D-/L-isoT) was performed on AS1411. They could promote the nucleotide-protein interaction by changing the local conformation. Twenty modified sequences were obtained, FCL-I and FCL-II showed the most not...