Differential Effects of PDE4 Inhibitors on Cortical Neurons and T-Lymphocytes
Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated the function of two catalytically active conformations of PDE4 (a low-affinity conformer detected by conventional cAMP hydrolytic activity an...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2008-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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